摘要:Background: This is a four year retrospective study of major limb amputations performed at BPKIHS, Dharan, Nepal, a premier medical centre of Eastern Nepal. Analysis of indications and complications of the surgical amputations are presented. Results: This patients were mostly males below the age of 40 years. Lower limb amputations constituted 75% while the rest were upper limb amputation. The commonest indication was trauma (42%) followed by traditional bone setter (TBS) gangrene (32%) and malignant tumours (14%). Wound infection, the commonest complication occurred in patients who had identifiable predisposing factors. The two deaths that occurred were in the patients who had traditional bone setter intervention and all died due to septicaemia. Conclusion: Trauma and traditional bone setter gangrene were the commonest indications. Most of the amputations were avoidable. Institution of preventable measures is imperative. Paying attention to predisposing factors can reduce complications.