文章基本信息

标题：اثر افزودن نالترکسون در درمان اسکیزوفرنیا: مقایسه دو سوکور با دارونما
其他标题：Naltrexone as an Adjunct to Treatment of Schizophrenia: A Double Blind Placebo Controlled Trial
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作者：ShS. Goodarzi ; M. Arbabi ; M. Samimi Ardestani 等
期刊名称：Iranian Journal of Psychiatry and Clinical Psychology
印刷版ISSN：1735-4315
电子版ISSN：2228-7515
出版年度：2006
卷号：12
期号：1
页码：49-54
语种：English
出版社：Tehran University of Medical Sciences
其他摘要：Abstract Introduction: Given the role of opioids and their antagonists on dopamine secretion, the effect of naltrexone use in the treatment of schizophrenia was evaluated in this study. Method: In a double blind placebo controlled clinical trial study on a group of 34 patients with schizophrenia on maintenance therapy with antipsychotics, 17 patients received naltrexone (50 mg, BID ) and 17 patients received placebo (BID) . The patients were evaluated at the start of the trial, as well as three and six weeks after, using Positive and Negative Syndrome Scale (PANSS) . Results: Patients receiving naltrexone showed improvement in positive symptoms from week three to week six, and improvement in negative symptoms from week one to week three. Conclusion: Naltrexone had no significant effect on positive or negative symptoms of schizo-phrenia compared to placebo.
关键词：کلیدواژه: اسکیزوفرنیا; نالترکسون; اپیویید; علایم منفی; علایم مثبت; درمان نگهدارنده
其他关键词：Key words: schizophrenia; naltrexone; opioid; positive symptoms; negative symptoms; maintenance therapy