Although propofol is thought to be a relatively safe intravenous anesthetic with regard to histamine release reactions, anaphylactoid reactions to propofol may sometimes occur, especially in patients with a history of allergy, atopy, or asthma. Here we report a patient with allergies to sesame leaves and cold medications who experienced an anaphylactic reaction with severe oropharyngeal edema a few minutes after receiving propofol (Anepol^®). This finding suggests that propofol should be used with caution in patients with a history of allergy. Because profound airway edema can occur, the airway should be evaluated before extubation of the trachea.