文章基本信息

标题：The Expression of alpha2-Adrenergic Receptor Subtypes in the Central Nervous System of Peripheral Nerve Injured Rats
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作者：Choi, So Ron ; Lee, Hyung Chang ; Chung, Chan Jong 等
期刊名称：Korean Journal of Anesthesiology
印刷版ISSN：2005-6419
出版年度：2006
卷号：51
期号：4
页码：468-475
DOI：10.4097/kjae.2006.51.4.468
语种：English
出版社：The Korean Society of Anesthesiologists,
摘要：
BACKGROUND: The change of expression of the alpha2-adrenergic receptor (alpha(2)-AR) subtypes in the thalamus and hypothalamus were investigated in a neuropathic pain rat model.

METHODS: The left sciatic nerve was clamped for creating a neuropathic pain model in five rats. A sham operation was done in three rats as control group. Behavioral tests for pain were conducted by using mechanical stimuli applied to the hind paws. After 7 days, the expression of alpha(2)-AR subtype mRNA in the rat thalamus and hypothalamus was measured using real time polymerase chain reaction.

RESULTS: Mechanical allodynia were developed on postoperative 1, 3, and 7 days in the neuropathic pain model. The expression of alpha(2A)-AR, alpha(2B)-AR, and alpha(2C)-AR was significantly higher in the thalamus and hypothalamus in the neuropathic pain model (P > 0.05).

CONCLUSIONS: These results would suggest that the subtypes of alpha(2)-AR in thalamus and hypothalamus may contribute to produce neuropathic pain.
关键词：alpha(2)-adrenergic receptor; Neuropathic pain; Peripheral nerve injury; Mechanical allodynia