文章基本信息

标题：Calix[8]arene Sulfonic Acid Catalyzed Three-Component Reaction for Convenient Synthesis of 3,4-Dihydropyrimidin-2(1 H )-ones/thiones under Ultrasonic Irradiation
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作者：Lin An ; Li-li Han ; Zu-jian Wang 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2016
卷号：39
期号：2
页码：267-271
DOI：10.1248/bpb.b15-00681
出版社：The Pharmaceutical Society of Japan
摘要：In this work, the catalytic activity of calix[8]arene sulfonic acid was successfully investigated for the famous Biginelli reaction. Under ultrasonic irradiation, calix[8]arene sulfonic acid could efficiently catalyzed the three-component reaction of aldehydes with ethyl acetoacetate and urea or thiourea in ethanol to afford the corresponding 3,4-dihydropyrimidin-2(1 H )-ones/thiones in 46–93%. The advantages of this method are the easy isolated procedure, short reaction time and low cost of the catalyst.