文章基本信息

标题：Case report of Mikulicz`s disease: A modern concept of an old entity
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作者：Božić, Ksenija ; Glišić, Branislava ; Radić-Tasić, Olga 等
期刊名称：Vojnosanitetski pregled
印刷版ISSN：0042-8450
出版年度：2016
页码：120-120
DOI：10.2298/VSP150118120B
出版社：Military Medical Academy, INI
摘要：Introduction. Modern knowlegde defines Mikulicz´s disease as a part of immunoglobulin G4-related disease. The main feature is the presence of lymphoplasmacytic infiltrates, immunoglobulin G4 plasma cells positivity, distinctive storiform fibrosis and moderate eosinophilia. Case report. A 59-years old male presented with a mild keratoconjuctivitis sicca and enlarged lacrimal and salivary glands during the last two years. Althought clinical presentation of the patient was typical, earlier testing did not pinpoint Mikulicz ´s disease. By typical clinical presentation, elevated serum immunoglobulin G4 level and histopathological finding of lacrimal glands tissue we diagnosed Mikulicz´s disease successfully treated with corticosteroid therapy. Conclusion. We reported the first case of IgG4-related Mikulicz´s disease in Serbia. Our report highlights IgG4-related Mikulicz` s disease as an important differential diagnosis with Sjögren`s syndrome and lymphoproliferative disease in rheumatological practice.
关键词：Mikulicz' disease; diagnosis; differential; diagnosis; lacrimal apparatus; salivary glands; immunoglobulin G; histological techniques; glucocorticoids; treatment outcome