文章基本信息

标题：Intra-Host Bayesian Phylogeography Linking Viral Evolution and Pathogenesis Comes to an Age
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作者：Brittany D. Rife ; Marco Salemi
期刊名称：British Journal of Virology
电子版ISSN：2055-6128
出版年度：2015
卷号：2
期号：4
页码：58-61
出版社：Smith and Franklin Academic Publishing Coporation
摘要：Bayesian phylogeographic analysis has recently been at the forefront of understanding ep- idemiological processes through the reconstruction of evolutionary history and spatial dissemination of pathogens. Infection of a single host can be viewed similarly as an epidemic spread on a microscale, creating a unique opportunity for the application of phylogeography at the intra-host level, which has until recently been limited by dataset quality and the lack of a rigorous statistical framework. As recently described in studies using the SIV-macaque model of neuroAIDS, the incorporation of spatial, temporal, and demographic inference into intra-host evolutionary analysis using Bayesian phylogeography allows for inference of pathogen migration between infected tissues and cell types, provides valuable insight into immunopathological processes, and ultimately paves the way for a bet- ter understanding of the interplay between viral evolution and pathogenesis.