文章基本信息

标题：Biological Relevance of C-terminal Elongation of the NS1 Protein of Influenza A Viruses
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作者：Weili Kong ; Guangpeng Ma ; Jinhua Liu 等
期刊名称：British Journal of Virology
电子版ISSN：2055-6128
出版年度：2014
卷号：1
期号：4
页码：112-115
出版社：Smith and Franklin Academic Publishing Coporation
摘要：The non-structural 1 (NS1) protein plays a crucial role in moderating the virulence of influenza virus by multiple mechanisms. Due to C-terminal 'tail' (CTT) truncation of NS1, there are length variation types of NS1 in different subtype influenza viruses. CTT functions in several ways to defeat the cellular innate immune responses. Here, we discuss those different effects of CTT trun- cation or elongation of NS1 protein in different genetic backgrounds of influenza experimentations. Conclusively, it can be stated that CTT confers a positive role during the infection of influenza A viruses. However, this regulation is contributed by multiple factors and has variable impact on the pathobiology of influenza A viruses.