文章基本信息

标题：HIV Tat Regulates the Immune Responses Induced by Vaccines
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作者：Ye Liu ; Yulong Cong ; Yiming Shao 等
期刊名称：British Journal of Virology
电子版ISSN：2055-6128
出版年度：2014
卷号：1
期号：2
页码：64-71
出版社：Smith and Franklin Academic Publishing Coporation
摘要：As the crucial transcription activator of HIV, Tat has been considered as an important immunogen for HIV vaccine candidates for a long time. However, HIV Tat also plays immunoreg- ulation roles in improving immune responses of vaccines. Herein, we review recent developments of HIV Tat as immunoregulator using for optimizing the efficacy of vaccines. By highlighting pre- clinical/clinical applications of Tat and its working mechanisms, this review exhibits the superior potential of Tat as immunoregulator on optimizing immune responses mediated by vaccines. These examples of selected studies will provide researchers some implications and inspirations for using HIV Tat to optimize immune responses of vaccines.