文章基本信息

标题：Isolation and In vitro characterization of anti-Gardnerella vaginalis bacteriocin producing Lactobacillus fermentum HV6b isolated from human vaginal ecosystem
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作者：Kaur B ; Balgir PP ; Mittu B 等
期刊名称：International Journal of Fundamental and Applied Sciences
印刷版ISSN：2278-1404
出版年度：2012
卷号：1
期号：3
页码：41-50
出版社：BioMedAsia
摘要：Background and Objective : Vaginal isolate HV6b is an agent that could be used to combat growing prevalence of sexually transmitted microbial infections and viral diseases. Therapeutic application of this probiotic strain to protect against gastrointestinal infections may be of great importance for future medicinal use. Methodology: Bacteriocin producing strains of lactic acid bacteria were isolated from vaginal swabs of healthy and fecund females and evaluated for their antimicrobial activity against pathogens causing important human diseases such as gastrointestinal infections, nosocomial and skin diseases. Results: Bacteriocin HV6b shows maximum inhibition against bacterial vaginosis causing G. vaginalis. It was identified as Lactobacillus fermentum on the basis of biochemical testing and 16S rDNA sequencing. Conclusion: Based on the antibiotic sensitivity profiles vaginal LABs, HV6b was suggested as a strain for formulating topical personal care therapeutics aimed at prevention and treatment of many human diseases.
关键词：Lactic acid bacteria; Bacterial vaginosis; Gardnerella vaginalis; Bacteriocin