文章基本信息

标题：DHA Effects in Brain Development and Function
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作者：Lotte Lauritzen ; Paolo Brambilla
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2016
卷号：8
期号：1
页码：6
DOI：10.3390/nu8010006
语种：English
出版社：MDPI Publishing
摘要：Docosahexaenoic acid (DHA) is a structural constituent of membranes specifically in the central nervous system. Its accumulation in the fetal brain takes place mainly during the last trimester of pregnancy and continues at very high rates up to the end of the second year of life. Since the endogenous formation of DHA seems to be relatively low, DHA intake may contribute to optimal conditions for brain development. We performed a narrative review on research on the associations between DHA levels and brain development and function throughout the lifespan. Data from cell and animal studies justify the indication of DHA in relation to brain function for neuronal cell growth and differentiation as well as in relation to neuronal signaling. Most data from human studies concern the contribution of DHA to optimal visual acuity development. Accumulating data indicate that DHA may have effects on the brain in infancy, and recent studies indicate that the effect of DHA may depend on gender and genotype of genes involved in the endogenous synthesis of DHA. While DHA levels may affect early development, potential effects are also increasingly recognized during childhood and adult life, suggesting a role of DHA in cognitive decline and in relation to major psychiatric disorders.
关键词：docosahexaenoic acid; brain development; desaturases; psychiatric disorders docosahexaenoic acid ; brain development ; desaturases ; psychiatric disorders