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标题：Change in Metabolic Profile after 1-Year Nutritional-Behavioral Intervention in Obese Children
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作者：Elvira Verduci ; Carlotta Lassandro
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2015
卷号：7
期号：12
页码：10089-10099
DOI：10.3390/nu7125520
语种：English
出版社：MDPI Publishing
摘要：Research findings are inconsistent about improvement of specific cardio-metabolic variables after lifestyle intervention in obese children. The aim of this trial was to evaluate the effect of a 1-year intervention, based on normocaloric diet and physical activity, on body mass index (BMI), blood lipid profile, glucose metabolism and metabolic syndrome. Eighty-five obese children aged ≥6 years were analyzed. The BMI z-score was calculated. Fasting blood samples were analyzed for lipids, insulin and glucose. The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated and insulin resistance was defined as HOMA-IR >3.16. HOMA-β%, quantitative insulin sensitivity check index and triglyceride glucose index were calculated. The metabolic syndrome was defined in accordance with the International Diabetes Federation criteria. At the end of intervention children showed a reduction (mean (95% CI)) in BMI z-score (−0.58 (−0.66; −0.50)), triglycerides (−0.35 (−0.45; −0.25) mmol/L) and triglyceride glucose index (−0.29 (−0.37; −0.21)), and an increase in HDL cholesterol (0.06 (0.01; 0.11) mmol/L). Prevalence of insulin resistance declined from 51.8% to 36.5% and prevalence of metabolic syndrome from 17.1% to 4.9%. Nutritional-behavioral interventions can improve the blood lipid profile and insulin sensitivity in obese children, and possibly provide benefits in terms of metabolic syndrome.
关键词：childhood obesity; nutritional-behavioral intervention; lipid profile; glucose metabolism; metabolic syndrome childhood obesity ; nutritional-behavioral intervention ; lipid profile ; glucose metabolism ; metabolic syndrome