文章基本信息

标题：3D Image-Guided Automatic Pipette Positioning for Single Cell Experiments in vivo
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作者：Brian Long ; Lu Li ; Ulf Knoblich 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
DOI：10.1038/srep18426
出版社：Springer Nature
摘要：We report a method to facilitate single cell, image-guided experiments including in vivo electrophysiology and electroporation. Our method combines 3D image data acquisition, visualization and on-line image analysis with precise control of physical probes such as electrophysiology microelectrodes in brain tissue in vivo . Adaptive pipette positioning provides a platform for future advances in automated, single cell in vivo experiments.