文章基本信息

标题：Flower-like PEGylated MoS₂ nanoflakes for near-infrared photothermal cancer therapy
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作者：Wei Feng ; Liang Chen ; Ming Qin 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
DOI：10.1038/srep17422
出版社：Springer Nature
摘要：Photothermal cancer therapy has attracted considerable interest for cancer treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can be applied clinically. In this study, we therefore develop flower-like molybdenum disulfide (MoS₂) nanoflakes and investigate their potential for photothermal ablation of cancer cells. MoS₂ nanoflakes are synthesized via a facile hydrothermal method and then modified with lipoic acid-terminated polyethylene glycol (LA-PEG), endowing the obtained nanoflakes with high colloidal stability and very low cytotoxicity. Upon irradiation with near infrared (NIR) laser at 808 nm, the nanoflakes showed powerful ability of inducing higher temperature, good photothermal stability and high photothermal conversion efficiency. The in vitro photothermal effects of MoS₂-PEG nanoflakes with different concentrations were also evaluated under various power densities of NIR 808-nm laser irradiation, and the results indicated that an effective photothermal killing of cancer cells could be achieved by a low concentration of nanoflakes under a low power NIR 808-nm laser irradiation. Furthermore, cancer cell in vivo could be efficiently destroyed via the photothermal effect of MoS₂-PEG nanoflakes under the irradiation. These results thus suggest that the MoS₂-PEG nanoflakes would be as promising photothermal agents for future photothermal cancer therapy.