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标题：The prognostic significance of thrombocytosis in ovarian cancer
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作者：Aneta Słabuszewska-Jóźwiak ; Ewa Dmoch-Gajzlerska ; Barbara Kozakiewicz 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2015
卷号：22
期号：4
页码：731-735
DOI：10.5604/12321966.1185785
出版社：Institute of Agricultural Medicine in Lublin
摘要：Ovarian cancer makes up 25–30% of all cases of cancers of the female genital tract. It has the highest mortality rate of anycondition in oncological gynaecology. Early diagnosis is associated with a favourable 5-year survival prognosis. Many solidtumours have been detected with concomitant thrombocytosis. The tumour cell-induced platelet aggregation is a result ofa direct integration of tumour cells with blood platelets. The aim of the present paper is an evaluation of platelet count as aprognostic parameter for ovarian cancer. Between 2000 – 2005, 349 patients with ovarian tumour (aged 12 – 88-years-old)underwent primary surgical treatment at a clinic. Ninety-seven patients with ovarian carcinomas underwent chemotherapyin the Oncology Centre. The control group comprised 252 women diagnosed with a histopathological lesion of mildintensity, whereas the cancer group constituted 97 women with a histopathologically-diagnosed malignant neoplasm.Thrombocytopaenia was assumed with a platelet count below 150G/L and thrombocythaemia at 350G/L and higher.Thrombocytosis often coincides with ascites and the cytoreduction decreases platelet count. There is a positive correlationbetween platelet count and tumour grading. Thrombocytosis was more frequently found in high grade tumours. There isalso a positive correlation between platelet count and tumour stage according the International Federation of Gynaecologyand Obstetrics (FIGO). Thrombocytosis was more frequently found in stage III and IV cancers. Patients with co-occurringthrombocytosis were found to have shorter survival periods and shorter time free from disease. This seems to give groundsfor measuring platelet count before the primary surgical intervention, and suggests that the platelet count should beincluded in the panel of prognostic factors for patients with ovarian tumours
关键词：platelet count; thrombocytosis; ovarian cancer