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标题：Superoxide dismutase and glutathione peroxidase activity in pregnancy complicated by diabetes
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作者：Artur Wdowiak ; Ireneusz Brzozowski ; Iwona Bojar 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2015
卷号：22
期号：2
页码：297-300
DOI：10.5604/12321966.1152083
出版社：Institute of Agricultural Medicine in Lublin
摘要：The objective of the study was determination of the activity of superoxide dismutase (SOD) and glutathione peroxidase(GPx) in blood and placental tissues of pregnant women with pregnancy complicated by diabetes, pregnant womenwith physiological pregnancy, and non-pregnant women, as well as a comparative analysis of blood and placental tissueparameters in the groups of women examined. The material for the study was blood and placental tissue from 50 pregnantwomen who received treatment due to insulin-dependent diabetes (PD). For the control group, 50 pregnant womenwithout diabetes (HP), and 30 non-pregnant women (NP) were selected. SOD activity in erythrocytes was evaluated by themethod of spectrophotometry with the use of RANSOD kit (RANDOX Laboratories Ltd., UK). The activity of GPx activity inerythrocytes was determined according to the method by Paglia and Valentine using RANSEL kit (RANDOX Laboratories Ltd).The results were subject to statistical analysis. Insulin-dependent diabetes in pregnancy affects the activity of anti-oxidativeenzymes. In the blood of women with pregnancy complicated by diabetes, the activity of anti-oxidative enzymes – SODand GPx is higher than in the blood of women with physiological pregnancy and the control group. In the placental tissuefrom pregnancy complicated by diabetes, the activity of SOD significantly decreases, while the activity of GPx increases,compared to women in physiological pregnancy
关键词：superoxide dismutase; glutathione peroxidase; pregnant women; diabetes