文章基本信息

标题：Prostate cancer in patients from rural and suburban areas – PSA value, Gleason score and presence of metastases in bone scan
本地全文：下载
作者：Wojciech Szot ; Magdalena Kostkiewicz ; Joanna Zając 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：4
页码：888-892
DOI：10.5604/12321966.1129953
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. Prostate cancer is the second most common neoplasm among men both worldwide and in Poland.In prostate cancer, bone metastasis is related to a poorer prognosis. A diagnosis of metastatic bone disease is important inprostate cancer patients prior to therapy. Prostate specific antigen (PSA) serum value is used both as a screening tool andfor staging of prostate cancer.Aim. To evaluate whether there is a link between symptoms presented by patients, pain in particular, and the presence,number and location of bone metastases as assessed by bone scan scintigraphy in concordance with PSA values and Gleasonscores.Material. A group of 186 patients (aged: 68.38±6.16) diagnosed with prostate cancer, from rural and suburban areas ofMałopolska province, that was directed for bone scan scintigraphy to the Nuclear Medicine Dept, John Paul II Hospital inKraków.Methods. Analysis of all laboratory findings (including PSA value) and a biopsy were performed. Then, bone scan scintigraphywas done with the use of methylene disphosphonate (MDP) labeled with Tc-99m.Results. In patients with a Gleason value ≤7 and a PSA value ≤20 ng/ml, the cutoff value for a negative bone scan with aconfidence interval of 0.95 was established at a PSA value below 10 ng/ml (p<0.01). Correlations were established betweenPSA value and presence of metastases in bone scan (r=0.45, p=0.05), the number of metastases (r=0.66, p<0.01), and theirpresence in particular body regions.Conclusions. The correlation between PSA value and both presence and number of metastases confirms the usefulness ofbone scan scintigraphy in prostate cancer staging. The cutoff value for negative bone scan with a 95% confidence intervalwas established at PSA = 10 ng/ml.
关键词：Prostate cancer; bone scan; metastases; PSA value