文章基本信息

标题：Disturbance of posture in children with very low lead exposure, and modification by VDR FokI genotype
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作者：Natalia Pawlas ; Karin Broberg ; Staffan Skerfving 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：4
页码：739-744
DOI：10.5604/12321966.1129926
出版社：Institute of Agricultural Medicine in Lublin
摘要：Lead has a negative effect on the central nervous system (CNS), inter alia indicated bydisturbance of posture. However, knowledge of the CNS effects at low exposure is insufficient. Individuals differ in vulnerability,possibly because of genetic predisposition. Polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD) and vitaminD receptor (VDR) genes may modify lead metabolism and neurotoxicity.The objective of the study was to determine whether very low lead exposure affects posture in children, and whether ALADand VDR genotypes modify the effect
关键词：balance; BsmI; central nervous system; gene-environment interaction; MspI; neurotoxicity; Pb; RsaI; rs1800435; rs1139488;rs2228570; rs731236; rs1544410; SNP; TaqI