文章基本信息

标题：Effect of isopropyl methylphosphonofluoridate (IMPF) poisoning on selected immunological parameters of angiogenesis
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作者：Robert Zdanowski ; Małgorzata Krzyżowska ; Sławomir Lewicki 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：4
页码：733-738
DOI：10.5604/12321966.1129925
出版社：Institute of Agricultural Medicine in Lublin
摘要：Acetylcholinesterase (AChE) and cholinergic receptors play an important role in the immunesystem, including lymphocyte-induced angiogenesis. However, their exact role is not fully understood. The presented worktests the influence of isopropyl methylphosphonofluoridate (IMPF), an irreversible inhibitor of AChE, on selected immuneparameters associated with angiogenesis in mice. The levels of VEGF, bFGF, TNF-α, and IFN-γ production were measured,together with the ability of lymphoid spleen cells to induce local GvH reaction after a single dose of IMPF
关键词：non-neuronal cholinergic system; cytokines; immunotoxicology; organophosphates