文章基本信息

标题：Matrix metalloproteinase 3 polymorphisms as a potential marker of enhanced susceptibility to lung cancer in chronic obstructive pulmonary disease subjects
本地全文：下载
作者：Kamil Brzóska ; Teresa Bartłomiejczyk ; Barbara Sochanowicz 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：3
页码：546-551
DOI：10.5604/12321966.1120599
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Chronic obstructive pulmonary disease (COPD) is often accompanied by lung cancer. Amongthe genes that may play a role in the occurrence of COPD and lung cancer are those encoding the proteolytic enzymes, suchas matrix metalloproteinases (MMPs) and their tissue inhibitors. The objective of this study was to find MMPs-associatedmarkers useful in the identification of COPD subjects with increased susceptibility to developing lung cancer.Materials and methods. We compared the frequency of single nucleotide polymorphisms in genes coding for matrixproteinases (MMP1, MMP2, MMP3, MMP9, MMP12) as well as tissue inhibitor of metalloproteinases (TIMP1) in two groups ofsubjects: COPD patients (54 subjects) and COPD patients diagnosed for lung cancer occurrence (53 subjects).The levels ofthe respective proteins in blood serum were also analyzed.Results. The frequencies of 2 genotypes, MMP3 rs3025058 and MMP3 rs678815, were significantly different between thestudied groups. In both cases, more heterozygotes and less homozygotes (both types) were observed in the COPD groupthan in the COPD + cancer group. A significantly higher TIMP1 level in blood serum was observed in the COPD + cancergroup than in the COPD group. There were no statistically significant differences in MMPs blood levels between the studiedgroups. In addition, no genotype-associated differences in TIMP1 or MMPs blood levels were observed.Conclusions. Homozygocity for MMP3 rs3025058 and rs678815 polymorphisms is a potential marker of enhanced susceptibilityto lung cancer development among COPD subjects
关键词：COPD; matrix metalloproteinase; lung cancer; MMP; inhibitors of metalloproteinases