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标题：Influence of dioxin intoxication on the human system and possibilities of limiting its negative effects on the environment and living organisms
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作者：Ireneusz Całkosiński ; Joanna Rosińczuk-Tonderys ; Justyna Bazan 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：3
页码：518-524
DOI：10.5604/12321966.1120594
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Despite the restrictive legal regulations related to the reduction of dioxins emission, theirconcentration in the environment is still too high. Mainly, this is related to the illegal utilisation of electronic equipmentand combustion of wastes, and also to intensified activity and maintenance of ships, especially in developing countries.The most important remaining source in Europe is the metal industry. Studies on the mechanism of impact of dioxins arestill being carried out. This review points at new possibilities for limiting the molecular mechanisms of dioxins activity, interalia, through the application of high doses of tocopherol and acetylsalicylic acid while treating dioxins intoxication.Brief description of the state of knowledge. Apart from the knowledge of dioxins affinity to the aryl hydrocarbon receptor(AhR), the multi-stage radical-form actions and the pro-inflammatory mechanism associated with cyclooxygenase-II enzyme(COX-2) are under intense investigation at the moment. Due to the high affinity of dioxins to animals adipose tissue and theirability to accumulate in it, they can enter the food chain. Furthermore, high dioxin doses can cause poisoning manifestedas advanced clinical symptoms, whereas in smaller doses, when cumulated, can cause metabolic changes which are oftendifficult to associate with their presence. Recently, some serious food contaminations by dioxins have been demonstrated.Sea fish and products from contaminated aqueducts still constitute potential sources of dioxins pollution.Conclusion. According to recent studies, dioxins are present in different concentrations in the environment and causespecific and long-time effects. These effects could be limited by the use of tocopherol and acetylsalicylic acid
关键词：aryl hydrocarbon receptor (AhR); dioxin; inflammatory; persistent organic pollutants; 2; 3; 7; 8-tetrachlorodibenzo-p-dioxin;(TCDD); tocopherol