文章基本信息

标题：The influence of lead on the biomechanical properties of bone tissue in rats
本地全文：下载
作者：Grazyna Olchowik ; Justyna Widomska ; Marek Tomaszewski 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：2
页码：278-281
DOI：10.5604/1232-1966.1108591
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Environmental lead (Pb) is a serious public health problem. At high levels, Pb is devastatingto almost all organs. On the other hand, it is difficult to determine a safe level of exposure to Pb. More than 90% of the Pb inthe adult human body and 70% in a child’s body is stored in the bones. In the presented study, the effects of lead exposureon bones were studied for rats treated orally with Pb acetate in drinking water for 14 days. The hypothesis was tested thatlead exposure negatively affects bone structure.Materials and methods. Femur strength was measured in a three-point bending test, whereas infrared spectroscopy (FTIR)was used to measure molecular structural changes.Results. Lead significantly decreased the ratio of area of two types of vibrational transitions, which are highly specific tomineral to matrix ratio. The results of the biomechanical study show that femurs of rats treated by Pb-acetate appeared tobe weaker than bones of the control group, and may produce a condition for the development of higher risk of fractures.Additionally, a great difference in body mass was observed between control and the Pb acetate-treated groups.Conclusions. The lower bone mineral content and the weaker mechanical properties of bones from Pb-treated rats areassociated with the pathologic state dependent of the exposure of lead
关键词：lead; FTIR; rat; mechanical properties of bones