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标题：Effect of treatment with N-acetylcysteine on non-enzymatic antioxidant reserves and lipid peroxidation in workers exposed to lead
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作者：Sławomir Kasperczyk ; Michał Dobrakowski ; Aleksandra Kasperczyk 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：2
页码：272-277
DOI：10.5604/1232-1966.1108590
出版社：Institute of Agricultural Medicine in Lublin
摘要：There are no published studies examining the effects of N-acetylcysteine (NAC) administration on the non-enzymatic defencesystems in humans exposed to lead. In view of this, it was decided to measure the levels of uric acid (UA), albumin, bilirubinand alpha-tocopherol before and after treatment with NAC. An estimation was also made of the degree of oxidative stressby measuring the ferric reducing ability of plasma (FRAP), the levels of conjugated dienes (CD) and lipid hydroperoxides(LHP). Male employees who worked with lead were randomized into two groups. The first group included workers whowere not administered any drugs (n=49), while the second group (n=122) consisted of workers who were treated withNAC at three different doses (200 mg, 400 mg and 800 mg) for 12 weeks. The administration of NAC (400 mg, 800 mg)resulted in significant decreases in the LHP levels. Similarly, a strong tendency toward lower levels of CD was observed inthe same groups. The UA levels were significantly lower only in the group receiving the 200 mg dose of NAC. However, thealpha-tocopherol levels were significantly elevated after treatment with NAC (400 mg, 800 mg). NAC administration didnot significantly affect the levels of bilirubin and albumin, but a tendency toward higher values was observed for FRAP.NAC reduced the extent of lipid peroxidation in a dose-dependent manner. Elevated concentrations of alpha-tocopherolmay have enhanced the beneficial effects of NAC. Treatment with NAC may contribute to the restoration of non-enzymaticantioxidant reserves when administered to lead-exposed workers
关键词：lead exposure; N-acetylcysteine; antioxidants; human