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标题：Alcohol- and water-based extracts obtained from Rhodiola rosea affect differently the number and metabolic activity of circulating granulocytes in Balb/c mice
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作者：Robert Zdanowski ; Sławomir Lewicki ; Ewa Skopińska-Różewska 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：1
页码：120-123
出版社：Institute of Agricultural Medicine in Lublin
摘要：Asia and now commonly used as adaptogens and antidepressants. The aim of the presented study was to examine thein vivo effect of aqueous (RRW) and 50% hydro-alcoholic (RRA) extracts on the number and metabolic activity of bloodgranulocytes in mice.Material and methods. Mice were fed for 7 days with RR extract at daily doses of 0.05, 0.1, 0.2 or 0.4 mg. The metabolicactivity of blood granulocytes was determined by measuring of their luminol-dependent chemiluminescent activity on ascintillation counter, after zymosan stimulation.Results. The number of blood granulocytes was diminished and their chemiluminescence was enhanced in all groups ofmice fed R.rosea hydro-alcoholic extract. Aqueous extract (RRW) was ineffective in all doses applied.Conclusion. The presented study revealed difference in the number and metabolic activity of granulocytes mice fed RRAor RRW extracts. Immune characteristics of some individual compounds from RRA and RRW extracts, selected by HPLCanalysis, should be carried out in subsequent experiments.
关键词：Rhodiola rosea; mice; granulocytes; chemiluminescence