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标题：Predictors of environmental lead exposure among pregnant women – a prospective cohort study in Poland
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作者：Kinga Polańska ; Wojciech Hanke ; Wojciech Sobala 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：1
页码：49-54
出版社：Institute of Agricultural Medicine in Lublin
摘要：Blood lead levels (BLL) in women of child-bearing age have been decreasing in recent decades, but still remains a concern forlong-term effects of child psychomotor development. The aim of the study was to characterize lead exposure among Polishpregnant women and assess the relationship between BLL and selected socio-demographic, economic and lifestyle factors.The study population consisted of 594 pregnant women who had been the subjects of the prospective Polish Mother andChild Cohort Study (REPRO_PL). The women were interviewed three times during pregnancy (once in each trimester). Leadconcentration in the blood collected during the second trimester of pregnancy was analyzed using graphite furnace atomicabsorption spectrometry (GF-AAS), or inductively coupled plasma mass spectrometry (ICP-MS). Active and passive smokingwas analyzed by the cotinine level in saliva using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Thelead level in the blood ranged from 0.3 – 5.7 μg/dL, with a geometric mean (GM) of 1.1 μg/dL (GSD ±0.2 μg/dL). Statisticallysignificant associations were found between BLL and factors such as maternal age (β=0.01; p=0.02), education (β=0.08;p=0.04) and prepregnancy BMI (β=0.1; p=0.001). Additionally, BLL increased with increasing cotinine level in saliva (β=0.02;p=0.06) and decreased with the increasing distance from the copper smelter (β=-0.1; p=0.009). Public health interventions,especially in regions with a higher level of exposure to lead, among women with lower SES and among smokers, are stillreasonable
关键词：Blood lead level; pregnancy; distance from smelter; cotinine