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标题：THE EFFECT OF PURSLANE SEEDS ON BIOMARKERS OF OXIDATIVE STRESS IN DIABETIC PATIENTS: A RANDOMIZED CONTROLLED CROSS?OVER CLINICAL TRIAL
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作者：ZAKIZADEH ELAHE ; FAGHIHIMANI ELHAM ; SANEEI PARVANEH 等
期刊名称：INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
印刷版ISSN：2008-7802
出版年度：2015
卷号：6
期号：10
页码：0-0
语种：English
出版社：ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
摘要：Background: This study was designed to examine the effects of purslane seeds on biomarkers of oxidative stress in type 2 diabetic patients.
Methods: This cross ? over randomized controlled clinical trial was conducted on 40 patients with type 2 diabetes. Participants were randomly assigned to receive either 10 g/day purslane seeds with 240 cc low ? fat yogurt (intervention group) or only 240 cc low ? fat yogurt (as a control group) for 5 weeks. After a 2 ? week washout period, subjects were moved to the alternate arm for an additional 5 weeks. At baseline and end of each study phase, fasting blood samples were collected to quantify biomarkers of oxidative stress.
Results: We observed a slight decrease in plasma total antioxidant capacity in both groups, however, between ? group changes were not significant (-2.67 vs. -2.95 m g/dL, P = 0.94). Plasma malondialdehyde in purslane group increased slightly, however, we observed no significant effect in the control group (1.62 vs. -0.47 m g/dL, P = 0.58). Although both groups had a slight reduction in plasma oxidized low ? density lipoprotein (ox ? LDL), we failed to find any significant effect of purslane on plasma ox ? LDL (-1.06 vs. -1.71 m g/dL, P = 0.85).
Conclusions: This cross ? over clinical trial revealed that consumption of purslane seeds for 5 weeks in type 2 diabetic patients did not result in improved oxidative stress.
关键词：DIABETES; MEDICINAL PLANT; OXIDATIVE STRESS; PURSLANE