文章基本信息

标题：Rab1 GTPases as oncogenes
本地全文：下载
作者：Yue Li ; Hui-Yun Wang ; X.F. Steven Zheng 等
期刊名称：Aging
出版年度：2015
卷号：7
期号：11
页码：897-898
出版社：U.S.Department of Health & Human Service
摘要：Rab1 is the founding member of the Rab small GTPase family, which is well known to mediate membrane trafficking between the endoplasmic reticulum (ER) and Golgi apparatus [1 ]. It is a highly conserved protein with two different isoforms, Rab1A and Rab1B in mammals, and predominantly localized on the membrane of endoplasmic reticulum (ER) and Golgi apparatus. The ER-Golgi membrane system is increasingly recognized for its role in anchoring cell signaling, where some key regulatory proteins such as mitogen receptors and transcription factors as are synthesized, modified and transported to the cell surface or nucleus. Consistently, some recent studies show that Rab1 is a regulator of several central signal transduction pathways, particularly mTOR pathway. A genetic screens in yeast identified Rab1 to be critical is for mediating amino acid (AA) signaling to activate mTORC1 [2 ]. The function of Rab1 in mTORC1 signaling was further investigated in yeast, human embryonic kidney (HEK) 293, and colorectal and liver cancer cells [2 , 3 ]. AA was found to stimulate Rab1A interaction with mTORC1 in the Golgi in a GTP- dependent manner, which further promotes the binding of Rheb to and activation of mTORC1 (Figure 1). Golgi is known for transducing signals of nutrients such as cholesterol into the nucleus. That mTOR is also localized in the nucleus where it regulates gene expression [4 ] raises an interesting possibility that Rab1 is especially important for activating AA-mTOR signaling into the nucleus.
关键词：Rab1;mTOR;Hepatocellular;Carcinomas;(HCC) ; Colorectal;Cancer.(CRC);nutrient;signaling