文章基本信息

标题：Systemic Problems: A perspective on stem cell aging and rejuvenation
本地全文：下载
作者：Irina M. Conboy ; Michael J. Conboy ; Justin Rebo 等
期刊名称：Aging
出版年度：2015
卷号：7
期号：10
页码：754-765
出版社：U.S.Department of Health & Human Service
摘要：This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are "beyond parabiosis" for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging.
关键词：parabiosis; aging; rejuvenation; stem cells; neurogenesis