文章基本信息

标题：Prognostic marker and target in prostate cancer
本地全文：下载
作者：Giovanni Lavorgna ; Francesco Montorsi ; Andrea Salonia 等
期刊名称：Aging
出版年度：2015
卷号：7
期号：10
页码：746-747
出版社：U.S.Department of Health & Human Service
摘要：In physiological conditions, Reactive Oxigen Species (ROS) are present in low amounts and their action can be effectively counteracted by the antioxidant system of the cells. However, cancer cells have higher ROS levels as a consequence of their increased metabolic activity, leading to a state of chronic oxidative stress. Increased levels of ROS are indeed involved in tumorigenesis and progression, conferring a growth advantage to malignant cells thanks to the upregulation of pathways stimulating proliferation and maintenance of the tumoral phenotype. In keeping with this point, cancer cells have a well-adapted antioxidant system to balance their increased generation of ROS [1].
关键词：ncRNA; biomarker; therapeutic; target ; apoptosis;prostate;cancer.