文章基本信息

标题：Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease
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作者：Alexey Moskalev ; Elizaveta Chernyagina ; João Pedro de Magalhães 等
期刊名称：Aging
出版年度：2015
卷号：7
期号：9
页码：616-628
出版社：U.S.Department of Health & Human Service
摘要：As the level of interest in aging research increases, there is a growing number of geroprotectors, or therapeutic interventions that aim to extend the healthy lifespan and repair or reduce aging-related damage in model organisms and, eventually, in humans. There is a clear need for a manually-curated database of geroprotectors to compile and index their effects on aging and age-related diseases and link these effects to relevant studies and multiple biochemical and drug databases. Here, we introduce the first such resource, Geroprotectors ( http://geroprotectors.org ). Geroprotectors is a public, rapidly explorable database that catalogs over 250 experiments involving over 200 known or candidate geroprotectors that extend lifespan in model organisms. Each compound has a comprehensive profile complete with biochemistry, mechanisms, and lifespan effects in various model organisms, along with information ranging from chemical structure, side effects, and toxicity to FDA drug status. These are presented in a visually intuitive, efficient framework fit for casual browsing or in-depth research alike. Data are linked to the source studies or databases, providing quick and convenient access to original data. The Geroprotectors database facilitates cross-study, cross-organism, and cross-discipline analysis and saves countless hours of inefficient literature and web searching. Geroprotectors is a one-stop, knowledge-sharing, time-saving resource for researchers seeking healthy aging solutions.
关键词：growth hormone receptor (GHR); muscle-specific knockout; lifespan; aging; frailty; pathology; body composition