文章基本信息

标题：ARF: Connecting senescence and innate immunity for clearance
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作者：Alper Y. Kearney ; Benedict Anchang ; Sylvia Plevritis 等
期刊名称：Aging
出版年度：2015
卷号：7
期号：9
页码：613-615
出版社：U.S.Department of Health & Human Service
摘要：We have found evidence suggesting that ARF and p53 are essential for tumor regression upon MYC inactivation through distinct mechanisms ARF through p53-independent affect, is required to for MYC to regulate the expression of genes that are required for both the induction of cellular senescence as well as recruitment of innate immune activation. Our observations have possible implications for mechanisms of therapeutic resistance to targeted oncogene inactivation.
关键词：Myc inactivation; p19arf; innate immunity; senescence