文章基本信息

标题：Infection causes childhood leukemia
本地全文：下载
作者：Julia Hauer ; Alberto Martín-Lorenzo ; Isidro Sánchez-García 等
期刊名称：Aging
出版年度：2015
卷号：7
期号：9
页码：607-608
出版社：U.S.Department of Health & Human Service
摘要：Leukemia accounts for a third of all cancers in children under the age of 15, mostly affecting industrialized countries, being the B-precursor acute lymphoblastic leukemia (pB-ALL) the most common type. The disease commonly strikes young children at the age of two to five years, and is treated with aggressive chemotherapy. In recent decades, more effective treatments have boosted survival rates and reduced mortality for childhood leukemia. However, according to SEER data from the National Cancer Institute, the incidence of lymphoblastic leukemia (ALL) in 0-14 year-old US children increased from 2.2 per 100,000 in 1975 to 4.0 per 100,000 in 2005. This might be caused in part due to better cancer registries but there is little doubt that the real incidence of this "modern life-style" malignancy also rose. Hence, preventive strategies are clearly superior to any therapy improvement. Environmental exposures came into the focus of many epidemiologists who initiated a number of well-conducted studies aiming to elucidate the etiological role of infection, nuclear power-plants, background terrestrial irradiation and many other putative factors.
关键词：leukemia;.infection;.murine.models;.genetic. ; susceptibility.