文章基本信息

标题：GDF11/Myostatin and aging
本地全文：下载
作者：Vishal K. Patel ; Fabio Demontis
期刊名称：Aging
出版年度：2014
卷号：6
期号：5
页码：351-352
出版社：U.S.Department of Health & Human Service
摘要：The aging of a multicellular organism is an intricate process that results from signaling events and age- related degeneration in cells, tissues, and organ systems. Studies in model organisms have provided evidence of unanticipated connection between local and systemic aging [1]. Research in this field is defining the key tissues that govern an organism's lifespan and the signals that convey information about the aging of cells and tissues throughout the organism [1]. Skeletal muscle is now being recognized as a prominent tissue with the capacity to influence systemic aging and lifespan [2, 3]. Many epidemiologic studies in humans have pointed to a remarkable connection between muscle strength and the morbidity and mortality linked to many age-related diseases [2]. The association between muscle function and aging has been corroborated by studies in model organisms. In mice and Drosophila, several muscle-restricted genetic interventions induce physiological responses in other tissues, such as regulation of lipid homeostasis in adipose tissue, regulation of insulin release, increased proteostasis, and decreased incidence of many age- related diseases [2, 3]. Although some of these systemic effects may be due to indirect effects of muscles' metabolic demand [2], there is also growing evidence for an endocrine role for skeletal muscle. In particular, muscle-derived cytokines and growth factors known as myokines are becoming recognized as important systemic regulators of metabolic homeostasis and may signal to many target tissues [2].