文章基本信息

标题：Efflux-mediated resistance identified among norfloxacin resistant clinical strains of group B Streptococcus from South Korea
其他标题：Efflux-mediated resistance identified among norfloxacin resistant clinical strains of group B Streptococcus from South Korea
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作者：Trang Nguyen Doan Dang ; Usha Srinivasan ; Zachary Britt 等
期刊名称：Epidemiology and Health
印刷版ISSN：2092-7193
出版年度：2014
卷号：36
DOI：10.4178/epih/e2014022
语种：English
出版社：Taehan P'ibu Kwahakhoe
摘要：OBJECTIVES: Group B Streptococcus (GBS), a common bowel commensal, is a major cause of neonatal sepsis and an emerging cause of infection in immune-compromised adult populations. Fluoroquinolones are used to treat GBS infections in those allergic to beta-lactams, but GBS are increasingly resistant to fluoroquinolones. Fluoroquinolone resistance has been previously attributed to quinolone resistance determining regions (QRDRs) mutations. We demonstrate that some of fluoroquinolone resistance is due to efflux-mediated resistance.
关键词：Fluoroquinolones; Norfloxacin; Ciprofloxacin; Levofloxacin; Moxifloxacin; Mutations; Efflux; Minimum inhibitory concentration