文章基本信息

标题：Global dynamics of a staged-progression model with amelioration for infectious diseases
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作者：Hongbin Guo ; Michael Y. Li
期刊名称：Journal of Biological Dynamics
印刷版ISSN：1751-3758
电子版ISSN：1751-3766
出版年度：2008
卷号：2
期号：2
页码：154-168
DOI：10.1080/17513750802120877
出版社：Taylor & Francis
摘要：We analyze the global dynamics of a mathematical model for infectious diseases that progress through distinct stages within infected hosts with possibility of amelioration. An example of such diseases is HIV/AIDS that progresses through several stages with varying degrees of infectivity; amelioration can result from a host's immune action or more commonly from antiretroviral therapies, such as highly active antiretroviral therapy. For a general n -stage model with constant recruitment and bilinear incidence that incorporates amelioration, we prove that the global dynamics are completely determined by the basic reproduction number R 0 . If R 0 ≤1, then the disease-free equilibrium P 0 is globally asymptotically stable, and the disease always dies out. If R 0 >1, P 0 is unstable, a unique endemic equilibrium P * is globally asymptotically stable, and the disease persists at the endemic equilibrium. Impacts of amelioration on the basic reproduction number are also investigated.
关键词：staged disease progression ; disease amelioration ; HIV/AIDS ; basic reproduction number ; global stability ; Lyapunov functions