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标题：Are saponins and sapogenins precursors of prednisolone? Preliminary results
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作者：Giuseppe Federico Labella ; Luca Maria Chiesa ; Sara Panseri 等
期刊名称：International Journal of Health, Animal Science and Food Safety
印刷版ISSN：2283-3927
出版年度：2015
卷号：2
期号：2s
DOI：10.13130/2283-3927/6447
语种：English
出版社：Department of Health, Animal Science and Food Safety (VESPA)
摘要：The transformation of cortisol into prednisolone in cattle faeces was demonstrated and provided by literature, given the structural similarity of prednisolone with cortisol. In this study, we evaluated a possible neo-formation of prednisolone, as results of a faecal or environmental contamination. A saponine, α-solanine, and a sapogenin, diosgenin, were selected as possible precursors. A simple method without extraction was applied. The analyses were performed by HPLC–MS n to evaluate the possible transformations. The results showed that prednisolone was detected in the faecal suspension spiked with diosgenin at t= 8h, while cortisol was also detected at t = 24h in the sample of faeces spiked with α-solanine. In the feed and in the control samples, no transformations were observed.
关键词：saponins;sapogenins;prednisolone;Saponins;sapogenins;prednisolone;neoformation;faeces;feed