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  • 标题:Deep and early molecular response induced by nilotinb in a newly diagnosed patient with chronic myeloid leukemia (CML)
  • 作者:Antonella Russo Rossi
  • 期刊名称:Clinical Management Issues
  • 印刷版ISSN:2283-3137
  • 出版年度:2013
  • 卷号:7
  • 期号:1S
  • 页码:19-23
  • DOI:10.7175/cmi.v7i1S.1144
  • 语种:Italian
  • 出版社:SEEd
  • 摘要:We report a case of a patient with chronic myeloid leukemia diagnosed in January 2012 and treated with nilotinib 600 mg/die as first line therapy. Patient obtained a complete hematologic response (CHR) and improvement of splenomegaly in 2 weeks. In three months the patient obtained complete cytogenetic response (CCR) and an important transcript level reduction (less than 1%). According to the international recommendations, molecular analysis was performed every three months in a LABNET network laboratory. Treatment was never interrupted or reduced due to any adverse event. After 9 months patient achieved a major molecular response (MMR) and during evaluation a MR4 has been documented.
  • 关键词:Clinical Medicine;Nilotinib; Chronic myeloid leukemia; BCR-ABL; Standardization Keywords: Nilotinib; Chronic myeloid leukemia; BCR-ABL; Standardization
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