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标题：Expressions of HPV 16-E6 in esophageal carcinoma and it’s clinical significance
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作者：Zhao Xing ; R Sahi ; Zhao Yu-Yang 等
期刊名称：Journal of Pathology of Nepal
印刷版ISSN：2091-0908
出版年度：2015
卷号：5
期号：9
页码：752-755
DOI：10.3126/jpn.v5i9.13786
语种：English
出版社：Association of Clinical Pathologists of Nepal (ACPN)
摘要：Background ? Gastrointestinal cancer is the most common malignant tumor in China. This research aims to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma. Materials and Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue. Results : The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had correlation with invasive depth (P<0.05), but not with patient age, lymph node metastasis, tumor size (P>0.05). Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma. Journal of Pathology of Nepal (2015) Vol. 5, 752-755
关键词：Esophageal carcinoma;HPV 16-E6 ;Immunohistochemistry