文章基本信息

标题：The Controversial Role of Food Allergy in Infantile Colic: Evidence and Clinical Management
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作者：Rita Nocerino
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2015
卷号：7
期号：3
页码：2015-2025
DOI：10.3390/nu7032015
语种：English
出版社：MDPI Publishing
摘要：Food allergies (FAs) are an increasing problem in Western countries, affecting up to 10% of young children. FAs are frequently associated with gastrointestinal manifestations. The role of FAs as a potential causative factor for infantile colic (IC) is still controversial. We report the most recent evidence on the pathogenesis, clinical and diagnostic aspects of FA-induced infantile colic (IC) and suggest a stepwise diagnostic approach. We selected articles on clinical and immunologic features, pathogenesis and management of FAs and IC from of 1981 to 2015. Original and review articles were identified through selective searches performed on PubMed, using the following terms: colic, infantile colic, food allergy and infantile colic, infantile colic treatment. The possible relationship between FAs and IC derives from the presence of dysmotility with visceral hypersensitivity and dysbiosis, demonstrated in both conditions, and the clinical response to dietary interventions. Unfortunately, the design of the studies, poor characterization of atopy and different dietary approaches limit the understanding of the importance of FAs in subjects with IC. The role of FAs in IC subjects without other symptoms of atopy remains controversial. However, where there is a suspicion of FAs, a short trial with an extensively hydrolyzed cow’s proteins formula or, if breast fed, with maternal elimination diet may be considered a reasonable option.
关键词：cow’s milk allergy; oral food challenge; skin prick test; atopy patch test; hypoallergenic formulas; intestinal microbiota; nutrition cow’s milk allergy ; oral food challenge ; skin prick test ; atopy patch test ; hypoallergenic formulas ; intestinal microbiota ; nutrition