文章基本信息

标题：Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL
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作者：Shalabh Dixit ; Akshaya Kumar Biswal ; Aye Min 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
DOI：10.1038/srep15183
出版社：Springer Nature
摘要：Sub-QTLs and multiple intra-QTL genes are hypothesized to underpin large-effect QTLs. Known QTLs over gene families, biosynthetic pathways or certain traits represent functional gene-clusters of genes of the same gene ontology (GO). Gene-clusters containing genes of different GO have not been elaborated, except in silico as coexpressed genes within QTLs. Here we demonstrate the requirement of multiple intra-QTL genes for the full impact of QTL qDTY _12.1 on rice yield under drought. Multiple evidences are presented for the need of the transcription factor ‘no apical meristem’ ( OsNAM _12.1) and its co-localized target genes of separate GO categories for qDTY _12.1 function, raising a regulon-like model of genetic architecture. The molecular underpinnings of qDTY _12.1 support its effectiveness in further improving a drought tolerant genotype and for its validity in multiple genotypes/ecosystems/environments. Resolving the combinatorial value of OsNAM _12.1 with individual intra-QTL genes notwithstanding, identification and analyses of qDTY _12.1has fast-tracked rice improvement towards food security.