文章基本信息

标题：Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form
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作者：Hyo Jung Seo ; Sang Hwan Nam ; Hyung-Jun Im 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
DOI：10.1038/srep15685
出版社：Springer Nature
摘要：In the field of nanomedicine, long term accumulation of nanoparticles (NPs) in the mononuclear phagocyte system (MPS) such as liver is the major hurdle in clinical translation. On the other hand, NPs could be excreted via hepatobiliary excretion pathway without overt tissue toxicity. Therefore, it is critical to develop NPs that show favorable excretion property. Herein, we demonstrated that micelle encapsulated ⁶⁴Cu-labeled upconverting nanoparticles (micelle encapsulated ⁶⁴Cu-NOTA-UCNPs) showed substantial hepatobiliary excretion by in vivo positron emission tomography (PET) and also upconversion luminescence imaging (ULI). Ex vivo biodistribution study reinforced the imaging results by showing clearance of 84% of initial hepatic uptake in 72 hours. Hepatobiliary excretion of the UCNPs was also verified by transmission electron microscopy (TEM) examination. Micelle encapsulated ⁶⁴Cu-NOTA-UCNPs could be an optimal bimodal imaging agent owing to quantifiability of ⁶⁴Cu, ability of in vivo / ex vivo ULI and good hepatobiliary excretion property.