文章基本信息

标题：Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study
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作者：Hanna Konttinen ; Clare Llewellyn ; Jane Wardle 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
DOI：10.1038/srep14726
出版社：Springer Nature
摘要：The mechanisms through which genes influence body weight are not well understood, but appetite has been implicated as one mediating pathway. Here we use data from two independent population-based Finnish cohorts (4632 adults aged 25–74 years from the DILGOM study and 1231 twin individuals aged 21–26 years from the FinnTwin12 study) to investigate whether two appetitive traits mediate the associations between known obesity-related genetic variants and adiposity. The results from structural equation modelling indicate that the effects of a polygenic risk score (90 obesity-related loci) on measured body mass index and waist circumference are partly mediated through higher levels of uncontrolled eating (β_indirect= 0.030–0.032, P indirect = 0.020–0.022, P indirect = 0.013–0.015, P = 0.043–0.044 in FinnTwin12). Our findings suggest that genetic predispositions to obesity may partly exert their effects through appetitive traits reflecting lack of control over eating or eating in response to negative emotions. Obesity prevention and treatment studies should examine the impact of targeting these eating behaviours, especially among individuals having a high genetic predisposition to obesity.