文章基本信息

标题：Identification and analysis of the N⁶-methyladenosine in the Saccharomyces cerevisiae transcriptome
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作者：Wei Chen ; Hong Tran ; Zhiyong Liang 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
DOI：10.1038/srep13859
出版社：Springer Nature
摘要：Knowledge of the distribution of N⁶-methyladenosine (m⁶A) is invaluable for understanding RNA biological functions. However, limitation in experimental methods impedes the progress towards the identification of m⁶A site. As a complement of experimental methods, a support vector machine based-method is proposed to identify m⁶A sites in Saccharomyces cerevisiae genome. In this model, RNA sequences are encoded by their nucleotide chemical property and accumulated nucleotide frequency information. It is observed in the jackknife test that the accuracy achieved by the proposed model in identifying the m⁶A site was 78.15%. For the convenience of experimental scientists, a web-server for the proposed model is provided at http://lin.uestc.edu.cn/server/m6Apred.php .