文章基本信息

标题：Chemokine polyreactivity of IL7Rα⁺CSF-1R⁺ lympho-myeloid progenitors in the developing fetal liver
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作者：Katja Kajikhina ; Fritz Melchers ; Motokazu Tsuneto 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2015
卷号：5
DOI：10.1038/srep12817
出版社：Springer Nature
摘要：In murine ontogeny, fetal liver is the major hemato- and B-lymphopoietic site until birth. Hematopoiesis develops in largely non-hematopoietic niches, which provide contacts, chemokines and cytokines that induce migration, residence, proliferation and differentiation of progenitors. Within early multipotent progenitors an IL7Rα⁺CSF-1R⁺ subset expressed a mixture of lymphoid- and myeloid-specific genes and differentiated to lymphoid and myeloid lineages in vitro . By contrast, IL7Rα⁺ cells were lymphoid-committed, and CSF-1R⁺ cells were erythro-myeloid-restricted. To respond to a multitude of chemokines single biphenotypic cells expressed CXCR4 and as many as five other chemokine receptors. The monopotent IL7Rα⁺ and CSF-1R⁺progenitors all expressed CXCR4, and mutually exclusive, more restricted sets of the analysed five chemokine receptors. This study proposes that chemokine polyreactive, cytokine-bipotent and monopotent progenitors transmigrate through LYVE-1^high endothelium, attracted by selected chemokines, and reach the IL7- and CSF-1-producing ALCAM^high mesenchymal niche, attracted by other sets of chemokines, to differentiate to B-lymphoid respectively myeloid cells.