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  • 标题:Synthesis of 2-Methyl -3,4,5,10-Tetrahydro-Pyrrolo [3,2-A] Carbazole- Ethyl Carboxylate Derivatives and Evaluation of their Binding Affinity with CT-DNA
  • 本地全文:下载
  • 作者:M. Saravanabhavan, V. Murugesan, M. Sekar1*ine
  • 期刊名称:Journal of Environmental Nanotechnology
  • 印刷版ISSN:2279-0748
  • 电子版ISSN:2319-5541
  • 出版年度:2013
  • 期号:3922
  • 页码:62-67
  • 出版社:Institute for Environmental Nanotechnology
  • 摘要:A new class of heterocyclic compound, substituted 2-methyl-3,4,5,10-tetarahydro-pyrrolo [3,2-a]carbazole-1-ethyl carboxylate derivatives have been prepared from 1-oxo-1,2,3,4,-tetrahydrocarbazoles. The structural features were determined by analytical and spectral techniques. DNA binding study of the compounds was investigated by absorption titration experiments which indicated that the compounds showed good binding affinity to CT-DNA via intercalation. Keywords: 1-oxo-1,2,3,4-tetrahydrocarbazole; DNA binding; Ethylaceto acetate; EI mass spectroscopy; NMR spectroscopy.
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