文章基本信息

标题：Pertussis booster vaccine for adolescents and young adults in São Paulo, Brazil
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作者：Angela Carvalho Freitas ; Valdir Okano ; Júlio Cesar Rodrigues Pereira 等
期刊名称：Revista de Saúde Pública
印刷版ISSN：0034-8910
出版年度：2011
卷号：45
期号：6
页码：1062-1071
语种：English
出版社：Universidade de São Paulo
摘要：OBJECTIVE: To develop a model to assess different strategies of pertussis booster vaccination in the city of São Paulo. METHODS: A dynamic stationary age-dependent compartmental model with waning immunity was developed. The “Who Acquires Infection from Whom” matrix was used to modeling age-dependent transmission rates. There were tested different strategies including vaccine boosters to the current vaccination schedule and three of them were reported: (i) 35% coverage at age 12, or (ii) 70% coverage at age 12, and (iii) 35% coverage at age 12 and 70% coverage at age 20 at the same time. RESULTS: The strategy (i) achieved a 59% reduction of pertussis occurrence and a 53% reduction in infants while strategy (ii) produced 76% and 63% reduction and strategy (iii) 62% and 54%, respectively. CONCLUSION: Pertussis booster vaccination at age 12 proved to be the best strategy among those tested in this study as it achieves the highest overall reduction and the greatest impact among infants who are more susceptible to pertussis complications.
其他摘要：OBJECTIVE: To develop a model to assess different strategies of pertussis booster vaccination in the city of São Paulo. METHODS: A dynamic stationary age-dependent compartmental model with waning immunity was developed. The “Who Acquires Infection from Whom” matrix was used to modeling age-dependent transmission rates. There were tested different strategies including vaccine boosters to the current vaccination schedule and three of them were reported: (i) 35% coverage at age 12, or (ii) 70% coverage at age 12, and (iii) 35% coverage at age 12 and 70% coverage at age 20 at the same time. RESULTS: The strategy (i) achieved a 59% reduction of pertussis occurrence and a 53% reduction in infants while strategy (ii) produced 76% and 63% reduction and strategy (iii) 62% and 54%, respectively. CONCLUSION: Pertussis booster vaccination at age 12 proved to be the best strategy among those tested in this study as it achieves the highest overall reduction and the greatest impact among infants who are more susceptible to pertussis complications.
关键词：Pertussis Vaccine; administration & dosage; Whooping Cough; prevention & control; Immunization Coverage; Mathematical Models.
其他关键词：Pertussis Vaccine; administration & dosage; Whooping Cough; prevention & control; Immunization Coverage; Mathematical Models.