文章基本信息

标题：PRENATAL DIAGNOSIS OF CONGENITAL TOXOPLASMOSIS: VALIDITY OF PCR USING AMNIOTIC FLUID AGAINST INDIRECT FLUORESCENT ANTIBODY ASSAY IN MOTHERS
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作者：ASMAR M. ; YASSAEI F. ; TERHOVANESIAN A. 等
期刊名称：Iranian Journal of Public Health
印刷版ISSN：2251-6085
电子版ISSN：2251-6093
出版年度：2004
卷号：33
期号：1
页码：1-4
语种：English
出版社：Tehran University of Medical Sciences
摘要：Maternal infection with Toxoplasma gondii acquired during pregnancy may result in congenital infection of developing fetuses. Up to now, decision on informed therapeutic abortion of fetuses suspected of having T. gondii infection in Iran has been made based on serological findings in mothers. This might have led to unnecessary abortion of many uninfected children. We evaluated the Polymerase Chain Reaction (PCR) assay on amniotic fluids against serological findings in mothers. PCR results in this study indicated that only about one third of Indirect Fluorescent Antibody (IFA) positive mothers had passed the infection to their children. It was a sigh of relief for the majority of mothers who learned that their infants were uninfected. On the other hand it helped the mothers of infected fetuses out of an awkward predicament by making them able to make a solid decision to terminate the pregnancy or carry their children to term.
关键词：TOXOPLASMA GONDII; CONGENITAL TOXOPLASMOSIS; PRENATAL DIAGNOSIS; PCR; IFA; IRAN.