文章基本信息

标题：PYRIMETHAMINE AND PROGUANIL RESISTANCE-CONFERRING KEY MUTATIONS IN DIHYDROFOLATE REDUCTASE GENE OF PLASMODIUM FALCIPARUM ISOLATES FROM IRAN
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作者：MASOUD A. ; KESHAVARZ H. ; MAHBOUDI F. 等
期刊名称：Iranian Journal of Public Health
印刷版ISSN：2251-6085
电子版ISSN：2251-6093
出版年度：2003
卷号：32
期号：4
页码：8-12
语种：English
出版社：Tehran University of Medical Sciences
摘要：Using mutation specific PCR assay and analysis of position 108 amino acid in dihydrofolate reductase-thymidilate synthase gene in 70 Plasmodium falciparum isolates of malarial patients from southern areas of Iran, showed 4 different situations: i- wild type (108-Ser) ii-mutant type (108-Thr) iii-mutant type (108-Asn) and iv-mixed wild and mutant type (108-Ser+Thr) with frequency of 58(82.8%), 2(2.9%), 8(11.4%) and 2(2.9%) respectively. Many studies have demonstrated that mutations in position 108 have key role for emerging resistance to anti-folate drugs in falciparum malaria so, the resistance to pyrimethamine and proguanil, presents in Plasmodium falciparum isolates from malarious endemic regions of Iran.
关键词：PLASMODIUM FALCIPARUM; DRUG RESISTANCE; PYRIMETHAMINE; PROGUANIL; IRAN