Dear Editor-in-Chief: We very much enjoyed reading a letter by Drs Joulaei and Motazedian published in an earlier issue of your journal (1). We are thankful to the authors for bringing this overlooked topic up and for opening a window of opportunity to discuss over the effectiveness of the Primary Health Care (PHC) system of Iran in control-ling HIV/AIDS in the country. The conclusions of this letter concern us, they stated that "PHC oriented health network system of Iran could play a key role in reaching out to high-risk groups, accelerating case findings and harm reduction intervention, and reducing high-risk sexual behavior in the HIV program". We do agree with some of the ideas presented in the letter, however, we think this approach may not be that feasible and practical in Iran based on the socio-cultural context of the country as well as the barriers against PHC.