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标题：SISTER CHROMATID EXCHANGES AND MICRONUCLEI IN LYMPHOCYTE OF NURSES HANDLING ANTINEOPLASTIC DRUGS
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作者：ANSARI LARI M. ; SAADAT M. ; SHAHRIARI M. 等
期刊名称：Iranian Journal of Public Health
印刷版ISSN：2251-6085
电子版ISSN：2251-6093
出版年度：2001
卷号：30
期号：1-2
页码：37-40
语种：English
出版社：THE SCHOOL OF PUBLIC HEALTH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
摘要：Individuals handling antineoplastic drugs or their wastes may absorb these potent genotoxic agents. The effects of handling antineoplastic drugs were examined in a group of 24 nurses working in the hematology and oncology departments of two different university hospitals in Shiraz (Iran) and in a group of 18 unexposed nurses as control group. The cytogenetic repercussions of exposure were assessed by examining sister chromatid exchanges (SCEs) and micronuclei (Mn) in circulating lymphocytes. A significant increased frequencies of SCE and Mn is observed in circulating lymphocytes.
A significant increased frequencies of SCE and Mn is observed in nurses in daily contact with antineoplastic drugs as compared to control group.
关键词：ANTINEOPLASTIC DRUGS ; SISTER CHROMATID EXCHANGE ; MICRONUCLEI ; OCCUPATIONAL EXPOSURE